The European Union has recently published its Mid-Point Progress Report on the 2021-2030 road safety strategy with the active contribution of NTUA. The results summarised in this Report illustrate how much can be achieved when actors at all levels – from individuals to EU-level governing structures – contribute to the Safe System approach, within their areas of responsibility. But the slow-down in progress towards Vision Zero – against a background of increased traffic growth and new societal and technological trends – calls into question whether the current road safety ‘toolbox’ is fit for the future. The Report reveals significant opportunities in order to ensure the EU remains on track to meet its 2030 objectives, namely: technological advances in vehicle safety, growing awareness of the economic benefits of investments in safety, an increasing political focus on sustainable mobility and the coordinated, sustained, and properly resourced efforts across the EU and within Member States at all levels of government and society.