The European Commission (EC) has adopted the EU Road Safety Policy Framework 2021-2030, in which emphasis has placed on monitoring the road safety progress at EU level. In view of that, it has been suggested to measure a set of eight road safety Key Performance Indicators (KPIs). The EC has been trying in parallel to develop the European Open Science Cloud (EOSC) ever since 2016, which is an open environment for hosting and processing research data. The objective of this paper is to explore the development of a road safety KPIs data ecosystem that could be integrated in the Transport Research Cloud as a subset of the EOSC platform. The paper describes the necessary steps to be taken in order to make the KPIs data open, as well as the concept and the governance plan of an open platform for road safety KPIs (OPEN RSPI). This has been done with the aim to make the platform exploitable by both the EC and the EU countries. From the practical point of view, there has been conducted a review of the available road safety KPIs in the ЕU, duly respecting the EOSC principles and requirements applicable to open data. The emphasis is placed on the data management plan requirements, as a component of a findable, accessible, interoperable, and reusable (FAIR) ecosystem, which allows collecting, storing and reusing the KPIs data across all EU countries. Finally, the focus has been on the opportunities and barriers for data sharing, which arise from opening up the KPIs data that should be taken into consideration when developing a platform. The development of an open platform provides researchers, practitioners, and road safety stakeholders at all levels to more promptly identify those critical factors that are contributing to road accidents and strengthen the proactive road safety management.