This paper discusses current European research in the area Intelligent Transport Systems (ITS) impact assessment and seeks to determine the future potential of such systems particularly as it pertains to road safety. The study focuses on investigating the anticipated impact of ITS using both previously undertaken research and expert opinions.  Several European studies on the impact of intelligent transport systems on road safety are presented, their findings are analyzed and the issues to be considered and be dealt with in the future are obtained. Furthermore, preliminary results from a large Delphi study on the issues regarding the impacts of system use on road safety are also presented and discussed. The results of this paper can assist in defining future needs and expectations from ITS on a European-wide level.