The proposed PhD thesis aims to investigate a framework for predictive safety assessment for all types of road users in urban areas, following selected interventions, and to investigate the risk factors in road safety. In order to achieve the research objective, traffic simulation models are combined with road safety performance data. In addition, elements such as human behaviour, mode choice and modal shift, demand forecasting of innovative mobility solutions and data on new and emerging mobility are introduced to provide and exploit additional information dimensions. The proposed doctoral research involves cutting-edge, exemplary research in the field of combining traffic simulation, road safety assessment and telematics. In particular, critical issues of logical relevance in the combination of these techniques will be critically examined. It is therefore expected that a wealth of technical, social and scientific results and conclusions will be produced.