The aim of this Diploma Thesis is to investigate the impact of various mobility characteristics on performance of Public Transport (PT) in terms of Public Transport trips, as well as on performance of road safety in terms of road fatalities. For this purpose, data from the annual reports of the European organization EMTA were used, which includes Public Transport Authorities from several large European cities and concerns data about population, road network, traffic and mobility. Furthermore, data on road fatalities from the European database CARE were also collected. A database was developed containing data from the two organizations for the period 2014 – 2018 and two different statistical models were developed, using the multiple linear regression for defining the factors that influence the demand of PT and road fatalities accordingly. Firstly, the application of the model indicates that more bus and tram stops, increase of GDP, higher population density and public operation of PT have a positive impact on PT demand in comparison to car ownership and the increase of PT fares with a negative impact on PT demand. Secondly, population density, bus and tram stops, modal share of active travelling modes (walking, cycling), GDP and tram speed lead to decrease of road fatalities.