The current diploma thesis aims to analyze the performance of road safety in the regions of Greece. For this purpose, the data of road accidents and the main characteristics of each region were used for the period 2010-2019 and two linear regression models were developed for all the regions of Greece, with and without Attica. From these models occurs that the number of deaths per 100.000 population depends on the income per inhabitant and the number of vehicles, the number of physicians (with Attica) and the density of each district (km²/inhabitant) and the unemployment (without Attica). Subsequently, the method of Data Envelopment Analysis (DEA) was utilized for the benchmarking of the 12 regions (except of Attica) based on their performance on road safety, depending on the population, the total income and the number of vehicles. According to this classification, Thessaly, Ionian islands and Central Macedonia appear to have the best road safety performances, while Peloponnese and South Aegean have the worst ones.