The objective of this paper is to investigate the effect of tourism on road accidents in Greece. For this reason, a data analysis for injury road accidents in Greece was conducted for the period 2011-2015. It was observed that road accidents and related casualties are increasing during touristic periods and the highest percentages of road accident casualties in touristic regions concern young people and Power Two Wheelers. Moreover, the accident fault risk per driver nationality and region was calculated by the use of the induced exposure method. It was found that foreign tourists have higher accident fault risk than Greeks and immigrants, and foreign tourists’ driver fault risk is much higher in non-touristic regions. The results of the analysis allow for an overall assessment of the road safety level in touristic and non-touristic regions in Greece, while some recommendations for enhancing safe tourism are also proposed.