The paper presents the results of the analysis of road safety data, collected within the research project “SaferAfrica – Innovating dialogue and problems appraisal for a safer Africa”, aiming to support policy makers and stakeholders with evidence on critical risk factors, related actions and good practices drawn from high quality data and knowledge. The project is funded by the European Union’s Horizon 2020 research and innovation programme. The overall objective is to identify key risk factors affecting road safety in African countries. More specifically, a data organisation and analysis system was developed for the data gathered in order to produce indicators and define critical areas and challenges per topic and region of Africa. The analysis of the data for identifying key risk factors was performed on 5 different topics and priority areas for road safety actions and interventions were highlighted.