Traffic accidents are the second most important cause of death for international tourists. In the present paper, this is related to differences in national road safety cultures (RSC). Previous research indicates that RSC, specified as shared expectations to other road users and perceptions of what is normal behaviour in traffic, continuously is (re)created through road user interaction in traffic settings. But what happens when road users from different RSCs interact? In the present paper, this process is examined focusing on the local driving population and international tourists on the Greek Island of Rhodes. The aims of the study are to examine: 1) To what extent do road safety cultures of international tourists and locals differ in Rhodes?, 2) Who is influenced by whom: Do the locals adapt their behaviour to the tourists, or is it the other way around?, 3) What are the (potential) safety outcomes of these processes?