In the unprecedented year of 2020, the rapid spread of COVID-19 disrupted everyday activities worldwide, leading the majority of countries to impose lockdowns and confine citizens to minimize the exponential increase in cases and casualties. The aim of this study is to present a descriptive overview of average driving speed and road crash data in correlation with the COVID-19 pandemic in Athens, Greece. Results indicated that during the lockdown periods, average speeds were increased by up to 8%, compared to the period with no restrictions. The imposition of another lockdown caused significant changes in Greek driving behavior, which was also depicted in the 37% increase on the road crashes. Policymakers should focus on the reduction and enforcement of speed limits, especially within urban areas as well as the reallocation of road space to cyclists and walkers in urban areas.