Implementing risk management to an entire organization, though being increasingly applied, may appear challenging, often perceived as requiring substantial effort with unclear benefits. This paper aims at providing road transport organizations and practitioners with key references and a roadmap for designing and implementing Enterprise Risk Management. The methodology relies on synthesizing existing good practices from the road transport sector. A brief overview of state-of-art practices with applications using different structures are provided and implementation drivers, expected benefits and maturity levels are highlighted. Practical considerations and key success factors are discussed, followed by the suggestion of an integrated implementation framework including key concepts and tools.