This Special Issue of Safety Science titled “RSS2022 Conference: Advanced Road Safety Analyses” compiles groundbreaking research presented at the 8th Road Safety and Simulation International Conference 2022 (RSS2022) that took place on 08–10 June 2022 at Zappeion Megaron in Athens, organized by the National Technical University of Athens (NTUA) and the Hellenic Institute of Transportation Engineers (HITE). This collection reflects a concerted effort to advance scientific knowledge in road safety, aiming to mitigate crash fatalities and injuries in the digital era through innovative quantitative research methods.