This paper presents a comparative analysis of two large scale databases with disaggregate data, the CARE system of the European Union and the FARS system of the United States.  The FARS system is already operational since 1975, whereas the CARE system is operational in pilot phase since 1995.  The comparative analysis of technical and operational characteristics of information input, output and processing methods used, identifies the possibilities for inter-state road accident analysis in the two continents. This analysis reveals not only the potential of the two systems but also the way road safety is treated in the two continents.