The objective of this research is the analysis of road safety attitudes and perceptions of motorcyclists with respect to riding a motorcycle while impaired (i.e. by alcohol, drugs / medication or fatigue) in Europe. Data are collected from the European SARTRE-4 survey, co-funded by the European Commission, which was conducted in 19 European countries. A total sample of 4,483 motorcyclists was interviewed in total, using a common questionnaire, with questions on road safety attitudes, perceptions, beliefs, motives etc. The present study allowed to identify differences in attitudes towards alcohol, medication and fatigue impaired riding, between groups of motorcyclists and different countries, and to assess the perceived impact of related road safety measures (e.g., legal blood alcohol concentration, breath testing and alcohol interlock) on intended behaviour.