The objective of this research is to develop and describe a methodology that allows building the structure of a European Road Safety Observatory (ERSO) that addresses these e-safety issues, identify the nature of the data that has to be stored in such an observatory, in a way that it is easily interpretable and usable, and finally to implement suitable methods for appropriate e-safety data analyses that will assess the most promising technological counter-measures. For this reason, a five-step methodology is developed. The analysis revealed that a well matched statistical analysis model is necessary for quantitative assessment of the e-Safety systems, indicating whether they address the real users’ needs revealed by the causation analysis. The expansion of the current benefits figures to an EU level and the analysis of the interactions between technology-based applications are considered to be the fundamental plinth upon which the relevant structure and data of ERSO are determined, allowing supplement other types of accident data and develop knowledge-based road safety policies at EU level.