This paper investigates the attitudes and behavior of Greek drivers with specific focus on mobile phone use while driving. The research is based on the data of the pan-European SARTRE 4 survey, which was conducted on a representative sample of Greek drivers in 2011. The analysis of the drivers’ behavior was carried out by the statistical methods of factor and cluster analysis. According to the results of factor analysis, Greek drivers’ responses in the selected questions were summarized into seven factors, describing road behavior, accident involvement probability, but also their views on issues concerning other drivers’ road behavior, enforcement for road safety and mobile phone use while driving. The results of cluster analysis indicated four different groups of Greek drivers: the cautious, the moderate, the conservative and the thoughtless drivers and the characteristics of each group where identified. These results may be useful for the appropriate design of targeted road safety campaigns and other countermeasures.