South-East European (SEE) countries are among the “worst road safety performers in Europe” based on road fatalities per population. The objective of this paper is the comprehensive presentation of the current road safety conditions in SEE as recorded within the EU co-funded project “ROSEE-ROad safety in South-East European regions”. Basic road safety trends, the assessment of road safety legislation, policy and institutional capacity and of needs and availability of road safety data and information in the project partner countries are recorded. Key issues on road infrastructure and road users’ behaviour are also explored and road safety priorities are set. This analysis provides a better understanding of the current road safety situation in SEE countries. Despite the great differences in road safety management, road network conditions, road user behaviour, social and economic background, legislation, enforcement etc, several common road safety problems exist and common priorities are set to tackle them.