In the framework of the development of the Strategic Plan for road safety in Greece, an extensive review of successful road safety measures world-wide took place, the results of which are presented in this paper.  Special emphasis was given to measures, which their effectiveness was proven through quantitative and / or qualitative evaluation. The measures considered varied from national scale information campaigns to local technical engineering measures, classified into a specially developed hierarchy, allowing for extraction of conclusions for best practices. This research identified the most promising measures for the improvement of road safety at local and national level in relation to the particular characteristics of the traffic environment and the user’s behaviour. At the same time, it has been proved that the critical success factors are the way these measures are implemented considering specific safety systems in the road environment, as well as the active participation of all deliverers concerned and road users.