This study proposes a novel methodology for assessing road infrastructure safety across relatively large road networks based on historic crash data. The developed methodology aligns with existing road safety assessment frameworks that focus on the identification of crash hotspot locations as it addresses the identification of crash hotspots and so, it can be easily adopted by practitioners. In addition to crash hotspot identification, it also provides a framework for a safety ranking of the network. Therefore, the final outcome of the methodology is the critically unsafe locations plus a characterization of the safety level of the rest network. This paper presents a series of analyses that aim at demonstrating the differences among the alternative approaches of implementing the methodology. This study contributes to the existing literature by introducing the concept of network-wide safety ranking and is useful for road safety stakeholders who are interested in more effective yet user-friendly methodologies related to road safety management.