Within this paper an attempt is made for the comparative assessment of road safety performance in Greece in relation to other European Union countries, by the use of a specially developed methodology. The «footprint» methodology was developed in the framework of the SUNflower+6, EU research project, aiming to support a comprehensive comparative analysis of road safety performance in various countries and / or regions. The core of the analysis lays on the trend of three elementary indicators over time; namely, personal risk (fatalities per unit of population), traffic risk (fatalities per unit of vehicle fleet) and fatality risk (fatalities per traveled vehicle-km). The analysis of the relationship between traffic risk and personal risk allowed for the interpretation of current trends of road safety performance in Greece, especially in relation to the performance of other Southern European countries.  Basic road accident causes were identified and related countermeasures were examined.