This paper presents an analysis of parameters affecting road safety in Greece. More precisely, the road user, the road environment as well as the vehicle are considered revealing the critical characteristics of each parameter. Special road user groups together with special road network and traffic types have been identified as requiring special treatment through legislation as well as information campaigns.  The comparison of road accident indices in Greece and the EU member states, the USA and Japan revealed that road safety level of Greece is relatively low.   This is mainly explained by the inappropriate road infrastructure and the lack of persistent implementation of road safety measures, together with the behavioural particularities of the Greek driver.  As a result of this parameters’ analysis affecting road safety in Greece, a number of priority recommendations is proposed at the end of the paper.