In Europe about 25% of road accident fatalities occur at junctions of various types, with the higher percentage (34%) being observed in the United Kingdom and the lower (<10%) in Greece. The objective of this research is the analysis of road safety related parameters in European road junctions through the use of the EU CARE database with disaggregate data on road accidents as well as of other international data sources (OECD/IRTAD, Eurostat, etc.). Time-series data from 16 EU countries over a period of 10 year (1997-2006) are correlated with basic safety parameters, such as junction geometric design, vehicle type, area type, gender of the driver, and weather and lighting conditions. During this period an overall decrease of almost 25 percent in traffic accident fatalities in junctions was observed, with values ranging between a decrease of 60% for France and an increase of 35% for Greece. The results of the analysis allow for an overall assessment of the road safety level in the European road junctions in comparison to the remaining road network, providing thus useful support to decision makers working for the improvement of safety in the European road network.