The first and the second Strategic Plan for the improvement of road safety in Greece were conducted by the Department of Transportation Planning and Engineering of NTUA within its contribution to the confrontation of the road accidents problem in Greece. In each one of the Plans, quantitative targets were set, a specific structure for the coordination of all involved parties was proposed and an integrated proposal regarding the implementation framework of the Plan was made. The lack of enactment and the fragmentary realization of the proposed measures included in the first Strategic Plan resulted in the reduction of road deaths during only the first period of its implementation. For the achievement of the second Strategic Plan target concerning the reduction of road deaths, enacted, systematic and serious effort is required.