Based on the Greek Road Safety Strategic Plan for the decade 2021-2030, Greece aims to reduce the number of fatalities and serious injuries in road crashes by 50% in 2030 compared to the 2019 level. Additionally, a set of key performance indicators (KPIs) for road safety has been established, which are related to the prevention of road crash casualties, to better monitor road safety progress during this decade. The objective of this study is to measure and assess road safety performance in Greece based on the KPIs on speeding, seat-belt use, helmet use, drink-driving, driver distraction and vehicle safety. The results of the analysis allow to evaluate road safety performance in Greece, providing also useful support to decision makers working for the improvement of safety in Greece, based on which proper and more targeted road safety measures can be taken.