The European Commission has put forward a new approach to EU road safety policy for the decade 2021-2030, highlighting also the need of setting new interim targets and establishing a range of key performance indicators (KPIs) for road safety at European level, which are directly related to the prevention of road accident fatalities and serious injuries. To measure progress and better understand the different issues affecting overall safety performance, a set of KPIs has been defined related to infrastructure safety, vehicle safety, safe road use including speed, alcohol, distraction and the use of protective equipment, and emergency response. The objective of this research is to provide an overview of a common methodology for the collection of the KPIs in the EU, present the principal guidelines for the data collection and the minimum expected results which will lead to the estimation of reliable and comparable KPIs at EU level.