Evidence based road safety policies are becoming more desirable and crucial for road safety improvements. The core of the SafetyCube project is a comprehensive analysis of accident risks and the effectiveness assessment and cost-benefit analysis of safety measures, focusing on road users, infrastructure, vehicles and post-impact care, framed within a Safe System approach, with road safety stakeholders at the national level, EU and beyond having involvement at all stages. The present work outlines the methods and outputs of developing the SafetyCube innovative road safety Decision Support System (DSS) which contains a wealth of road safety information.