An NTUA Diploma Thesis titled “Correlation between fatigue and driver behavior in urban and highway environments using simulator” was recently presented by Ioannis Paschalidis. To achieve this goal, an experimental procedure was conducted using a driving simulator, which collected driving data from 35 participants. In addition, a questionnaire survey was used to determine the participants’ personal characteristics. Results indicate that driving while fatigued increases drivers’ average speed and reaction time, decreases their distance from lead vehicles, and decreases their acceleration. Furthermore, milder symptoms of fatigue while driving are linked to shorter distances from the leading vehicle, compared to more severe symptoms, while also inducing an increase in acceleration.