Older adults comprise the fastest growing part of the population worldwide, an issue with far reaching implications to mobility and road safety. Interactions between the vehicle and Intelligent Transportation Systems (ITS), communication systems and technologies for continuously collecting data on drivers’ behavior may enhance the safety of elderly road users. The present paper reviews existing literature dedicated to the effectiveness of in-vehicle ITS to older drivers’ safety. Emphasis is given to the intersection control, the lateral/longitudinal control, as well as the parking, the night vision and the general navigation. Finally, some future research directions focused on elderly safety and in-vehicle ITS are discussed.