The World Health Organization (WHO) and the World Bank jointly issued the World Report on Road Traffic Injury Prevention on World Health Day 2004, dedicated by the WHO to the improvement of global road safety. The report’s publication signaled a growing concern in the global community about the scale of the health losses associated with escalating motorization and a recognition that urgent measures had to be taken to sustainably reduce their economic and social costs. Implementing the report’s recommendations has become a high priority for low and middle-income countries and the guidelines presented in this report have been prepared to assist this task.