The World Health Organization has released the 2nd edition of the Road Safety Manual for Powered Two- and Three-Wheeler (PTW) Safety. This 2nd edition offers guidance to help decision makers and practitioners put in place a comprehensive set of laws, regulations and actions needed to save lives. Rooted in new case studies and evidence, including from low- and middle-income countries, it includes guidelines on developing safer roads, ensuring safer mobility for all road users, vehicle safety standards, and actions to improve emergency responses to crashes.