A paper titled “Effect of Apolipoprotein E4 on the Driving Behavior of Patients with Amnestic Mild Cognitive Impairment or Mild Alzheimer’s Disease Dementia“, authored by E. Stanitsa, A. Economou, I. Beratis, D. Kontaxopoulou, S. Fragkiadaki, V. Papastefanopoulou, D. Pavlou, P. Papantoniou, C. Kroupis, J. Papatriantafyllou, L. Stefanis, G. Yannis and S. Papageorgiou is published in the Journal of Alzheimer’s Disease.  The results of this paper indicate that the lower speed variability of APOE4 carriers in the absence of neuropsychological test differences indicates reduced speed adaptations, possibly as a compensatory strategy. Simulated driving may be a sensitive method for detecting performance differences in the absence of cognitive differences.