The Global Road Safety Partnership (GRSP) organised with great success the Global Regional Road Safety Observatories (GRRSO) Dialogue on Powered Two-Wheeler Safety, that was held as a hybrid event (in Manila, Philippines and online) on 11-12 October 2022. The event brought together an unprecedented range of global experts and practitioners striving to address deaths and serious injuries resulting from motorcycle crashes. Additionally, it provided a unique opportunity to address issues relating to countries and cities where powered two-wheelers are the predominant form of transport.