The 2018 Polis Conference on “Transport innovation for sustainable cities and regions” took place with great success on 22 and 23 November 2018, in Manchester, UK, organised by POLIS, the European Cities Network. The conference provided an opportunity for cities, metropolitan areas and regions to showcase their transport achievements to a large audience, and for the wider transport community to engage with representatives of local and regional authorities on innovative transport solutions. Road Safety was one of the key areas of the Conference, as is also the subject of the special joint POLIS–ITF workshop titled: From Safety Data to Safer City Streets. The 2018 Polis Conference was the most successful edition ever, with a record number of 550 participants. In 2019, the annual event will return to Brussels, and will celebrate the network’s 30th anniversary.