The Swedish National Road and Transport Research Institute (VTI) is organising the Road Safety on Five Continents (RS5C) Conference, which will be held in Grapevine, Texas, on 10-12 October 2022. The Conference aims to be a leading source of research results and interaction in the transport area with focus on safety and health associated with road transport. By providing a platform for sharing knowledge and a forum to discuss mutual problem and their solutions, researchers, officials and other stakeholders can learn from results, experiences and success stories.