The Swedish National Road and Transport Research Institute (VTI) in cooperation with the University of Leeds organized with great success the Road Safety on Five Continents (RS5C) Conference, which took place in Leeds, United Kingdom, on 3-5 September 2025. The Conference aimed to be a leading source of research results and interaction in the transport area with focus on safety and health associated with road transport NTUA actively contributed with the following papers, posters and presentations: